Saturday 27. 8.
14:00-16:00 ARRIVAL/REGISTRATION OF THE PARTICIPANTS (Alvisse Parc Hotel)
16:15 Bus transportation to venue
17:00-17:15 WELCOME: Raymond BAUSCH, National Research Fund, and Robert KANZ, Public Research Center for Health
17:15-18:15 OPENING LECTURE : Eric KARSENTI Self-Organization Principles and Mitotic Spindle Morphogenesis
19.00-22:15 Dinner followed by informal get-together
22:30 Bus transportation to Hotel
Sunday 28. 8.
8:50-10:30 Session 1
STRUCTURE AND ASSEMBLY OF CYTOSKELETON COMPLEXES
Chair: Joël Vandekerckhove
8:50-9:00 Evelyne FRIEDERICH
Welcome and opening remarks
9:00-9.30 Toshio YANAGIDA
Dynamic Polymorphism of Actin Molecules in the Filament
9:30-10:00 Ueli AEBI
Can We Ever Determine the Structure of Intermediate Filaments at Atomic Detail?
10:00-10:15 Heidi ROMMELAERE
Characterization of Alpha-Skeletal Muscle Actin Mutants Causing Nemaline Myopathy: Expression in Cultured Skeletal Muscle Cells Causes Various Aberrant Phenotypes (P84)
10:15-10:30 Bernhard WEHRLE-HALLER
The Mechanism and Dynamics of Avb3 Integrin Clustering in Living Cells (P98)
10:30-11:00 COFFEE BREAK
11:00-12:40 Session 2
MOLECULAR MOTORS
Chair: André Steinmetz
11:00-11:30 Manfred SCHLIWA
Molecular Mechanics of the Kinesin Motor
11:30-12:00 Mark MOOSEKER
Defining the In Vivo Functions for Enterocyte Class I Myosin, Myosin-Ia (Myo1a)
12:00-12:15 Kristopher CLARK
TRPM7, a Novel Regulator of Actomyosin Contractility and Cell Adhesion (P15)
12:15-12:30 Sébastien SCHAUB
Mapping the Movement and Assembly of Filamentous Actin and Myosin II in Migrating Fish Epidermal Keratocytes (P87)
12:40-14:30 LUNCH
14:30-16:30 Session 3
CYTOSKELETAL DYNAMICS 1
Chair: Victor Small
14:30-15:00 Marie-France CARLIER
Control Mechanisms of Actin Polymerisation
15:00-15:30 Alexander BERSHADSKY
Coordinated Regulation of the Actin Cytoskeleton and Microtubule Dynamics by mDia1 Formin
15:30-15:45 Heather LONG
Subcellular Distribution of Cytoplasmic Linker Proteins in Migrating Epithelial Carcinoma Cells (P10)
15:45-16:00 Alphée MICHELOT
The Formin Homology 1 Domain Modulates the Actin Nucleation and Bundling Activity of Arabidopsis FORMIN1 (AFH1) (P59)
16:00-16:30 COFFEE BREAK
16:30-17:45 Session 4 CYTOSKELETAL DYNAMICS 2
Chair: Christophe Ampe
16:30-17:00 Tijs KETELAAR
Root Hairs: a Model System for Studying Cytoskeletal Dynamics and Cell Expansion
17:00-17:15 Céline REVENU
What is the Role of Villin in Cell Dynamics ? (P81)
17:15-17:30 Gemma BELLETT
Microtubule Plus-End Capture and the Formation of Non- Centrosomal Microtubule Arrays (P6)
17:30-17:45 Roser PINYOL
The Actin Binding Protein ABP1 Interacts with N-WASP and this Complex May Link Actin Dynamics to Endocytosis (P74)
19:30-20:30 DINNER
20:30 Posters and refreshments POSTER SESSION I
Monday 29. 8.
9:30- 12:00 Session 5 - SPECIAL SESSION
LIVE CELL IMAGING AND EMERGING TECHNOLOGIES
Chair: Mario Gimona
9:30-10:00 Klemens ROTTNER
WASP versus WAVE: Differential Subcellular Distribution, Dynamics and Function
10:00-10:30 Rainer PEPPERKOK
Studying the Coupling of ER Exit to Microtubules in Living Cells
10:30-11:00 COFFEE BREAK
11:00-10:15 Pirta HOTULAINEN
Two Distinct Assembly Mechanisms are Utilized in Generation of the Actin Stress Fiber Network (P39)
11:15-11:30 Suha NAFFAR-ABU-AMARA
Involvement of Motility- and Adhesion-Related Genes in Tumor Metastasis (P64)
11:30-11:45 Julien COLOMBELLI
In Vivo Cytoskeleton Dynamics Quantification by Pulsed UV Laser Nanosurgery (P16)
12:00-13:50 LUNCH
13:50-15:40 Session 6
NUCLEAR FUNCTION OF CYTOSKELETAL PROTEINS
Chair: Christine Chaponnier
13:50-14:20 Richard TREISMAN
Coupling Cytoskeletal Dynamics to the Regulation of Gene Transcription
14:20-14:50 Roland FOISNER
Lamina Proteins in Nuclear Architecture, Dynamic Chromatin Organization and Cell Cycle Control
14:50-15:15 Avri BEN-ZE’EV
Nuclear Function of Cytoskeletal Proteins: Coordinating Adhesion and Transcription by Novel Target Genes of Cadherin-Catenin Signaling in Colon Cancer (P7)
15:15-15:30 Jens GRUBER
RNAi of FACE1 Protease Results in Growth Inhibition of Human Cells Expressing Lamin A; Implications for Hutchinson-Gilford Progeria Syndrome (P36)
15:40-16:10 COFFEE BREAK
16:10-17:40 Session 7
MODEL ORGANISMS
Chair: Roger Karlsson
16:10-16-40 Angelika NOEGEL
Dictyostelium, a Model to Assess the Function of Cytoskeletal Proteins
16:40-17:10 Jürgen WEHLAND
Bacterial Pathogens as Models for the Dissection of Cytoskeleton Dynamics
17:10-17:25 Raissa ELUERE
A New Role for the Axial Budding Protein Bud3 in Regulating Septins Network for Cytokinesis in Saccharomyces cerevisiae (P26)
17:25-17:40 Sawako YAMASHIRO (P101)
UNC-87, C. elegans Calponin-Repeat Protein, Inhibits both F-Actin- Binding and Severing Activities of ADF/cofilin
19:00-20:00 BUFFET DINNER
20:00 Posters and refreshments POSTER SESSION II
Tuesday 30. 8.
9:00-12:10 Session 8
INTEGRATED CYTOSKELETAL CIRCUITS
Chair: Daniel Louvard
9:00-9:30 Mary BECKERLE
LIM Proteins: Molecular Scaffolds for Cytoskeletal Regulation and Signaling
9:30-10:00 Guy TANENTZAPF
Talin: an Essential Link between Integrins and the Cytoskeleton
10:00-10:30 Monique ARPIN
Plasma Membrane Organization and Cell Growth Signaling by the Membrane-Cytoskeleton Linker Ezrin
10:30-11:00 COFFEE BREAK
11:00-11:30 Giorgio SCITA
Signaling Complexes Regulating Actin Nucleation and Barbed End Capping Activity
11:30-11:45 Chen LUXENBURG
The Src-Cortactin Pathway Regulates Podosome Dynamics During Osteoclast Polarization (P54)
11:45-12:00 Pierre-Jean WIPFF
Mechanical Stress Induces Immediate TGF-b Activation in Myofibroblast Culture (P99)
12:45-13:45 LUNCH
13:45-15:30 Posters + coffee POSTER     SESSION III
15:30-20:00 Excursion to the Moselle (boat trip, visit of a winery + wine tasting)
20:00 GALA DINNER     Poster prizes
Wednesday 31. 8.
9:00-10:30 Session 9
BIOPHYSICS OF THE CYTOSKELETON
Chair: Benny Geiger
9:00-9:30 Cécile SYKES
Biomimetic Systems to Study Actin-Based Movement and Force Generation
9:30-10:00 Marileen DOGTEROM
Dynamics of Force-Generating Microtubules and Microtubule Bundles
10:00-10:15 Laurent KREPLAK
Evaluating the Mechanics of Single IFs In Vitro - towards Understanding the Mechanical Role of Ifs In Situ (P47)
10:15-10:30 Jan W. VOS
Measuring and Modeling Microtubule Organisation in Interphase Tobacco BY-2 Cells (P96)
10:30-11:00 COFFEE BREAK
11:00-12:15 Session 10
CYTOSKELETON AND DISEASE
Chair: Olli Carpen
11:00-11:30 FRANS RAMAEKERS
Mechanical Weakness of Nuclei and Cells in Laminopathies Result from Both Lamin Disorganization land Cytoskeletal Abnormalities
11:30-12:00 John S. CONDEELIS
The Invasion Signature of Mammary Tumours: Insights into Cell Signalling and Motility
12:00-12:15 Johan DE ROOIJ
Integrin-Dependent Acto-Myosin Contraction Regulates Epithelial Cell Scattering (P22)
12:15-14:00 LUNCH
DEPARTURE